Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 42 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
9
Cod liver oil aids rheumatoid arthritis
In a recent study involving 43 patients suffering from rheumatoid arthritis, we explored the impact of taking 1 gram of cod liver oil daily for three months. The results were striking. We observed notable reductions in morning stiffness by an impressive 52.4%, alongside decreases in both painful and swollen joints, each showing a 40% improvement. Pain intensity also saw a significant drop of 67.5%.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Read More
9
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Read More
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
Most Useful Reviews
9
Supports thyroid health
3 people found this helpful
Vitamin A in the form of retinol palmitate is ideal for absorbing beta-carotene, along with vitamins D and E. Its role in thyroid health is critical, as deficiency is linked to autoimmune disorder (AIT). Vitamin A can lower TSH levels and protect the thyroid, even with iodine deficiency. In hypothyroidism, it's important to replenish vitamin A as it is hard to obtain from plant sources. I take one capsule daily; it has been helpful for my health.
Read More
6
Reduced inflammation
2 people found this helpful
Wonderful! I ordered it for the first time, and the quantity and quality are excellent for the price. It has significantly helped my eczema, reducing inflammation. Fish oil, rich in omega 3, is also beneficial for hair. The product lasts two years. The size of the box is good, and while it has no taste, I recommend taking it with food to avoid any lingering oil smell. I highly recommend this product for managing autoimmune disorder symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 42 Researches
7.6
- All Researches
9
Cod liver oil aids rheumatoid arthritis
In a recent study involving 43 patients suffering from rheumatoid arthritis, we explored the impact of taking 1 gram of cod liver oil daily for three months. The results were striking. We observed notable reductions in morning stiffness by an impressive 52.4%, alongside decreases in both painful and swollen joints, each showing a 40% improvement. Pain intensity also saw a significant drop of 67.5%.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Read More
9
Vitamin A enhances rheumatoid arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
Read More
9
We explored an innovative treatment for autoimmune arthritis using microparticles that release all-trans retinoic acid (ATRA), a form of vitamin A. This method aims to enhance immune responses in a targeted way, improving T cells that help reduce inflammation.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Read More
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
9
We investigated a cutting-edge method using engineered nanoparticles to deliver all-trans retinoic acid (ATRA) directly to synovial fibroblasts in rheumatoid arthritis (RA). This approach utilizes a unique Golgi-targeting system to ensure effective treatment.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports thyroid health
3 people found this helpful
Vitamin A in the form of retinol palmitate is ideal for absorbing beta-carotene, along with vitamins D and E. Its role in thyroid health is critical, as deficiency is linked to autoimmune disorder (AIT). Vitamin A can lower TSH levels and protect the thyroid, even with iodine deficiency. In hypothyroidism, it's important to replenish vitamin A as it is hard to obtain from plant sources. I take one capsule daily; it has been helpful for my health.
Read More
6
Reduced inflammation
2 people found this helpful
Wonderful! I ordered it for the first time, and the quantity and quality are excellent for the price. It has significantly helped my eczema, reducing inflammation. Fish oil, rich in omega 3, is also beneficial for hair. The product lasts two years. The size of the box is good, and while it has no taste, I recommend taking it with food to avoid any lingering oil smell. I highly recommend this product for managing autoimmune disorder symptoms.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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